Safely Using Quetiapine

John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD

Pharmacy Times

January 2010

1. Grimm SW et al. Effects of cytochrome P450 3A modulators ketoconazole and carbamazepine on quetiapine pharmacokinetics. B J Clin Pharmacol. 2005;61:58-69.

2. Schulz-DuBois C et al. Major increase of quetiapine steady-state plasma concentration following co-administration of clarithromycin: confirmation of the pharmacokinetic interaction potential of quetiapine. Pharmacopsychiatry. 2008;41:258-259.

3. Grimm SW et al. Effects of cytochrome P450 3A modulators ketoconazole and carbamazepine on quetiapine pharmacokinetics. B J Clin Pharmacol. 2005;61:58-69.

4. Nickl-Jockschat T et al. Drug interaction can lead to undetectable serum concentrations of quetiapine in the presence of carbamazepine. Clin Neuropharmacol. 2009;32:55-56. Letter

5. Castberg I, et al. Quetiapine and drug interactions: evidence from a routine therapeutic drug monitoring service. J Clin Psychaitry 2007;68:1540-1545.

6. Aichhorn W, et al. Influence of age, gender, body weight and valproate comedication on quetiapine plasma concentrations. Int Clin Psychopharmacol. 2006;21:81-85.

7. Rahman A et al. Evaluating the incidence of leukopenia and neutropenia with valproate, quetiapine, or the combination in children and adolescents. Ann Pharamcother. 2009;43:822-30.

8. Uehlinger C, et al. Increased (R)-methadone plasma concentrations by quetiapine in cytochrome P450s and ABCB1 genotyped patients. J Clin Psychopharmacol. 2007;27:273-278.