Pharmacy Times – April 2011

Drug Interactions: Insights and Observations

Time Course for Enzyme Induction and De-induction

John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD

References

1. Horn JR et al. Disaster: Failing to consider the time course of drug interactions. Pharm Times. 2006(March);72: 30.

2. Reitman ML et al. Rifampin’s acute inhibitory and chronic inductive drug interactions: Experimental and model-based approaches to drug-drug interaction trial design. Clin Pharmacol Ther. 2011;89:234-242.

3. Ohnhaus E et al. Urinary excretion of 6β-hydroxycortisol and the time course measurement of enzyme induction in man. Eur J Clin Pharmacol. 1989;36:39-46.