Drug Interactions:
Insights and Observations
Life-Threatening
Colchicine Drug Interactions
John
R. Horn, PharmD, FCCP, and Philip Hansten, PharmD
References:
1. Dogukan A, et
al. Acute fatal colchicine intoxication in a patient on continuous ambulatory
peritoneal dialysis (CAPD). Possible role of clarithromycin administration.
Clin Nephrology. 2001;55:181-182.
2. Rollot F et al.
Acute colchicine intoxication during clarithromycin administration. Ann
Pharmacother. 2004;38:2074-77.
3.
Cheng VC et al. Two probable cases of serious drug interaction between
clarithromycin and colchicine. South Med J. 2005;98:811-813.
4.
Caraco Y et al. Acute colchicine intoxicationpossible role of erythromycin
administration. J Rheumatol. 1992;19:494-6.
5.
Phanish MK, Bloodworth LLO. Colchicine-induced rhabdomyolysis. Am J Med.
2003;114:166-167. Letter.
6.
Vasudevan AR et al. Colchicine-induced rhabdomyolysis: the whole is greater
than the sum of its parts! Am J. Med. 2003;115:249. Letter.
7.
Trger U et al. Tetraparesis associated with colchicine is probably due to
inhibition by verapamil of the P-glycoprotein efflux pump in the blood-brain
barrier. BMJ. 2005;331:613.
8. Hung IFN et al.
Fatal interaction between clarithromycin and colchicine in patients with renal
insufficiency: a retrospective study. Clin Infect Dis. 2005;41:291-300.