Avoiding Lapatinib Interactions

November 2012

John R. Horn, PharmD, FCCP, and Philip D. Hansten, PharmD

References:

1. Teo YL et al. Efffect of CYP3A4 inducer dexamethasone on hepatotoxicity of lapatinib: clinical and in vitro evidence. Breast Cancer Res Treat. 2012;133:703-711.

2. Smith DA et al. Effects of ketoconazole and carbamazepine on lapatinib pharmacokinetics in healthy subjects. Br J Clin Pharmacol. 2009;67:421-426.