Pharmacy Times – December 2006

Drug Interactions: Insights and Observations

Cranberry Juice: Does it Increase the Response to Warfarin?

John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD

References

1. Suvarna R et al. Possible interaction between warfarin and cranberry juice. BMJ. 2003;327:1454.
2. Grant P. Warfarin and cranberry juice: an interaction: J Heart Valve Dis. 2004;13:25-6.
3. Rindone JP et al. Warfarin-cranberry juice interaction resulting in profound hypoprothombinemia and bleeding. Am J Ther. 2006;13:283.
4. Duthie GC et al. Increased salicylate concentrations in urine of human volunteers after consumption of cranberry juice. J Agric Food Chem. 2005;53:2897.
5. Greenblatt DJ et al. Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies. Clin Pharmacol Ther. 2006;79:125.
6. Horn JR et al. Fruit juice interactions. Pharmacy Times. 2005;71:16.