Pharmacy Times – December 2009

Drug Interactions: Insights and Observations

Drug Interactions with St. John’s Wort

John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD

References

1. Horn J and Hansten P. St. John’s Wort Interactions: What’s New? Pharmacy Times. May, 2004, 62.

2. Piscitelli SC et al. Indinavir concentrations and St. John’s wort. Lancet. 2000;355:547-548.

3. Wang XD et al. Rapid and simultaneous determination of nifedipine and dehydronifedipine in human plasma by liquid chromatography-tandem mass spectrometry: application to a clinical herb-drug interaction study. J Chromatrog B. 2007;852:534-544.

4. Smith P et al. The influence of St. John’s wort on the pharmacokinetics and protein binding of Imatinib mesylate. Pharmacotherapy. 2004;24:1508-1514.