Get
to Know an Enzyme: CYP2C8
John
R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD
References.
1.
Rendic S et al. Human cytochrome P450 enzymes: a
status report summarizing their reactions, substrates, inducers and inhibitors.
Drug Metab Rev. 1997;29:413-580.
2.
Totah RA et al. Cytochrome P450 2C8: substrates,
inhibitors, pharmacogenetics, and clinical relevance. Clin Pharmacol Ther. 2005;77:341-52.
3.
Niemi M et al. Effects of gemfibrozil, itraconazole,
and their combination on the pharmacokinetics and pharmacodynamics of
repaglinide: potentially hazardous interaction between gemfibrozil and
repaglinide. Diabetologia. 2003;46:347-51.