Pharmacy Times – December 2016

Drug Interactions: Insights and Observations

Miconazole Oral Gel Drug Interactions

John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD

References

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8 Murakami S, Tanaka A, Ido K, et al. Prolonged effects of miconazole oral gel on warfarin anticoagulation even after treatment withdrawal. Int J Clin Pharmacol Ther. 2016;54:474-6.

9 O'Reilly RA, Goulart DA, Kunze KL, et al. Mechanisms of the stereoselective interaction between miconazole and racemic warfarin in human subjects. Clin Pharmacol Ther. 1992;51:656-67.

10 Gronlund J, Saari TI, Hagelberg N, et al. Miconazole oral gel increases exposure to oral oxycodone by inhibition of CYP2D6 and CYP3A4. Antimicrob Agents Chemother. 2011;55:1063-7.

11. Ishiwata Y, Nagata M, Arai T, et al. Effects of miconazole oral gel on blood concentrations of tacrolimus and cyclosporine: a retrospective observational study. Ther Drug Monit. 2016; PMID:27559841, Epub ahead of print.