Pharmacy Times – December 2017

 

Drug Interactions: Insights and Observations

 

Oral Anticoagulants and NSAIDs or SSRIs/SNRIs

 

John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD

 

References

 

1.     de Abajo FJ, Garcia-Rodriguez LA, Monero D. Association between selective serotonin reuptake inhibitors and upper gastrointestinal bleeding: population based case-control study. BMJ. 1999;319:1106-9.

2.     de Abajo FJ, Garcia-Rodriguez LA. Risk of upper gastrointestinal tract bleeding associated with selective serotonin reuptake inhibitors and venlafaxine therapy. Arch Gen Psychiatry. 2008;65:795-803.

3.     Masclee GM, Valkhoff VE, Coloma PM, et al. Risk of upper gastrointestinal bleeding from different drug combinations. Gastroenterology. 2014;147:784-92.

4.     Vitry AI, Roughead EE, Ramsay EN et al. Major bleeding risk associated with warfarin and co-medications in the elderly population. Pharmacoepidemiol Drug Saf. 2011;20:1057-63.

5.     Loke YK, Trivedi AN, Singh S. Meta-analysis: gastrointestinal bleeding due to interaction between selective serotonin uptake inhibitors and non-steroidal anti-inflammatory drugs. Aliment Pharmacol Ther 2008;27:31–40.

6.     Schalekamp T, Klungel OH, Souverein PC et al. Increased bleeding risk with concurrent use of selective serotonin reuptake inhibitors and coumarins. Arch Intern Med. 2008;168:180-5.

7.     Cochran KA, Cavallari LH, Shapiro NL et al. Bleeding Incidence With Concomitant Use of Antidepressants and Warfarin. Ther Drug Monit. 2011;33:433–8.