Pharmacy Times – February 2014
Drug Interactions: Insights and Observations
Kinase Inhibitors: An Update
John R. Horn, PharmD,
FCCP and Philip D. Hansten, PharmD
References
- Horn JR, Hansten PD, Drug Interactions with
Tyrosine Kinase Inhibitors. Pharmacy Times. 2010;76(April):37.
- Hardy KD, et al. Studies on the Role of
Metabolic Activation in Tyrosine Kinase Inhibitor-Dependent
Hepatotoxicity: Induction of CYP3A4 Enhances the Cytotoxicity of Lapatinib
in HepaRG Cells. Drug Metab Dispos. 2014;42:162-71.
- Teo YL, et al. Effect of CYP3A4 inducer dexamethasone on
hepatotoxicity of lapatinib: clinical and in vitro evidence. Breast Cancer Res Treat. 2012;133:703-11