Pharmacy Times – February 2015

 

Drug Interactions: Insights and Observations

 

DDI-Induced Gastrointestinal Bleeding

 

John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD

 

 

 

 

References

1. Rooney PJ, Hunt RH. The risk of upper gastrointestinal haemorrhage during steroidal and non-steroidal anti-inflammatory therapy. Baillieres Clin Rheumatol. 1990 Aug;4(2):207-17.

2. Jiang HY, Chen HZ, Hu XJ, et al. Use of Selective Serotonin Reuptake Inhibitors and Risk of Upper Gastrointestinal Bleeding: A Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol. 2015;13:42-50.

3. Coleman CI, Sobieraj DM, Winkler S, et al. Effect of pharmacological therapies for stroke prevention on major gastrointestinal bleeding in patients with atrial fibrillation. Int J Clin Pract. 2012;66:53-63.

4. Dalton SO, Johansen C, Mellemkjaer L, et al. Use of selective serotonin reuptake inhibitors and risk of upper gastrointestinal tract bleeding. Arch Intern Med. 2003;163:59-64.

5. Masclee GMC, Valkhjoff VE, Coloma P et al. Risk of upper gastrointestinal bleeding from different drug combinations. Gastroenterology. 2014;147:784-92.

6. Gulmez SE, Lassen At, Aalykke C et al. Spironolactone use and the risk of upper gastrointestinal bleeding: a population-based case-control study. Br J Clin Pharmacol 2008;66:294-9.