Oral Contraceptives and St John’s wort

January 2018

John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD

References:

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2. Soleymani S, Bahramsoltani R, Rahimi R, Abdollahi M. Clinical risks of St John’s wort (Hypericum perforatum) co-administration. Expert Opin Drug Metab Toxicol. 2017 Oct;13(10):1047-1062.

3. Berry-Bibee EN, Kim M-J, Tepper NK, Riley HEM, Curtis KM. Co-administration of St John’s wort and hormonal contraceptives: a systematic review. Contraception. 2016;94:668-677.

4. Hall SD, Wang Z, Huang SM, et al. The interaction between St John's wort and an oral contraceptive. Clin Pharmacol Ther 2003;74:525–535.

5. Murphy PA, Kern SE, Stanczyk FZ, Westhoff CL. Interaction of St. John's wort with oral contraceptives: effects on the pharmacokinetics of norethindrone and ethinyl estradiol, ovarian activity and breakthrough bleeding. Contraception 2005;71:402–408.

6. Pfrunder A, Schiesser M, Gerber S, Haschke M, Bitzer J, Drewe J. Interaction of St John's wort with low-dose oral contraceptive therapy: a randomized controlled trial. Clin Pharmacol 2003;56:683–90.