Pharmacy Times – July 2017

Drug Interactions: Insights and Observations

Piperine Drug Interactions

John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD

References.

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2. Pattanaik S, Hota D, Prabhakar S, Kharbanda P, Pandhi P. Pharmacokinetic interaction of single dose of piperine with steady-state carbamazepine in epilepsy patients. Phytother Res. 2009;23:1281-1286.

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4. Bedada SK, Boga PK, Kotakonda HK. Study on influence of piperine on the pharmacokinetics of diclofenac in healthy volunteers. Xenobiotica 2017;47:127-132.

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7. Bedada SK, Boga PK. The influence of piperine on the pharmacokinetics of fexofenadine, a P-glycoprotein substrate, in healthy volunteers. Eur J Clin Pharmacol. 2017; 73:343-349.

8. Bedada SK, Boga PK. Effect of piperine on CYP2E1 enzyme activity of chlorzoxazone in healthy volunteers. Xenobiotica. 2016. DOI:10.1080/00498254.2016.1241450.

9. Bano G, Raina RK, Zutshi U, Bedi KL, Johri RK, Sharma SC. Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers. Eur J Clin Pharmacol. 1991;41:615-617.