Pharmacy Times – June 2017

 

Drug Interactions: Insights and Observations

 

Direct Acting Oral Anticoagulants: Update on Drug Interactions

 

John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD

 

 

 

References:

 

1. Corallo C, Grannell L, Tran H. Postoperative bleeding after administration of a single dose of rivaroxaban to a patient receiving antiretroviral therapy. Drug Saf. 2015;2:11. DOI 10.1007/s40800-015-0014-4.

2. Stollberger C, Bastovansky A, Finsterer J. Fatal intracerebral bleeding under rivaroxaban. Internat J Cardiol. 2015;201:110. DOI:10.1016/j.ijcard.2015.06.081.

3. Fralick M, Juurlink DN, Marras T. Bleeding associated with coadministration of rivaroxaban and clarithromycin. CMAJ. 2016;188:669. DOI:10.1503/cmaj.150580.

4. Stollberger C, Finsterer J. Recurrent venous thrombosis under rivaroxaban and carbamazepine for symptomatic epilepsy. Neurol Neurochir Pol. 2017;51:194. DOI: 0.1016/j.pjnns.2017.01.010.

5. Gordon LA, Kumar P, Brooks, KM et al. Antiretroviral boosting agent cobicistat increases the pharmacokinetic exposure and anticoagulant effect of dabigatran in HIV-negative healthy volunteers. Circulation. 2016;134:1909. DOI: 10.1161/circulationaha.116.025257.

6. Hager N, Bolt J, Albers L et al. Development of left atrial thrombus after coadministration of dabigatran etexilate and phenytoin. Can J Cardiol. 2017;33:554. DOI: 10.1016/j.cjca.2016.10.022.

7. Wiggins BS, Northrup A, Johnson D et al. Reduced anticoagulant effect of dabigatran in a patient receiving concomitant phenytoin. Pharmacotherapy. 2016;36:e5. DOI: 10.1002/phar.1698.