Pharmacy Times – March 2017

Drug Interactions: Insights and Observations

Adverse Outcomes in Stabilized Patients

John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD

References.

1. Patel S, Andres J, Qureshi K. An unexpected interation between sofosbuvir/ledipasvir and atorvastatin and colchicine causing rhabdomyolysis in a patient with impaired renal function. Case Rep Med. 2016;2016:3191089.

2. Davis MW, Wason S. Effect of steady-state atorvastatin on the pharmacokinetics of a single dose of colchicine in healthy adults under fasted conditions. Clin Drug Investig. 2014;34:259-267.