Antiplatelet Effects of Aspirin:
Which NSAIDs Interact?
May 2013
John R. Horn, PharmD, FCCP and Philip
D. Hansten, PharmD
References
1. Hohlfeld
T, et al. High on treatment platelet reactivity against aspirin by
non-steroidal anti-inflammatory drugs—pharmacological mechanisms and
clinical relevance. Thromb Haemost.
2013;109: doi:10.1160/TH12-07-532
2. Catella-Lawson
F, et al. Cyclooxygenase inhibitors and the antiplatelet effects of aspirin. N Engl J Med. 2001;345:1809-1817.
3. Meek IL, et al.
Interference of NSAIDs with the thrombocyte inhibitory effect of aspirin: a
placebo-controlled, ex vivo, serial placebo-controlled serial crossover study. Eur J Clin Pharmacol. 2012;DOI
10.1007/s00228-012-1370-y.
4. Gladding PA, et al. The antiplatelet effect of six non-steroidal anti-inflammatory
drugs and their pharmacodynamic interaction with aspirin in healthy volunteers. Am J Cardiol.
2008;101:1060-1063.
5. Capone MI, et al.
Pharmacodynamic interaction of naproxen with low-dose aspirin in healthy
subjects. JACC 2005:45:1295-1301.
6. Anzellotti
P, et al. Low-dose naproxen interferes with the antiplatlet
effects of aspirin in healthy subjects: recommendations to minimize the
functional consequences. Arthritis Thrum. 2011;63:850-859.
7. Livio
M, et al. Indomethacin prevents the long-lasting effects of aspirin on human
platelet cyclo-oxygenase activity. Prostaglandins. 1982;23:787-796.
8. Gengo
FM, et al. Effects of ibuprofen on the magnitude and duration of aspirinÕs
inhibition of platelet aggregation: clinical consequences in stroke
prophylaxis. J Clin Pharmacol. 2008;48:117-122.
9. Rimon
G et al. Coxibs interfere with the action of aspirin
by binding tightly to one monomer of cyclooxygenase-1. Proc Natl
Acad Sci USA. 2009;107:28-33.
10. Farkouh
ME, et al. Cardiovascular outcomes in high risk patients with osteoarthritis
treated with ibuprofen, naproxen or lumiracoxib. Ann
Rheum Dis. 2007;66:764-770.
11. Kimmel SE, et al. The effects of nonselective non-aspirin non-steroidal
anti-inflammatory medications on the risk of nonfatal myocardial infarction and
their interaction with aspirin. J AM Coll Cardiol. 2004;43:985-990.
12. Ridker
PM, et al. Low-dose aspirin therapy for chronic stable angina. A randomized, placebo-controlled clinical trial. Ann Intern
Med. 1991;114:835-839.
13. MacDonald TM, Wei L.
Effect of ibuprofen on cardioprotective effect of
aspirin. Lancet. 2003;361:573-574.
14. Hennekens
CH, et al. Hypothesis formulation from subgroup analyses: nonadherence
or nonsteroidal anti-inflammatory drug use explains the lack of clinical
benefit of aspirin on first myocardial infarction attributed to Òaspirin
resistance.Ó Am Heart J. 2010;159:744-748.
15. Fischer LM, et al.
Current use of nonsteroidal anti-inflammatory drugs and the risk of acute
myocardial infarction. Pharmacotherapy. 2005;25:503-510.
16. Garcia Rodriguez LA,
et al. Nonsteroidal antiinflammatory drugs and the
risk of myocardial infarction in the general population. Circulation. 2004;109:3000-3006.