Pharmacy Times – November 2014

 

Drug Interactions: Insights and Observations

 

Codeine Drug Interactions

 

John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD

 

 

References.

 

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11. Gasche Y et al. Codeine intoxication associated with ultrarapid CYP2D6 metabolism. N Engl J Med. 2004;351:2827-31.

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15. Meissner K, et al. Cyclosporine-inhibitable blood-brain barrier drug transport influences clinical morphine pharmacodynamics. Anesthesiology. 2013:119:941-953.

16. Tzvetkov MV, et al. Morphine is a substrate of the organic cation transporter OCT1 and polymorphisms in OCT1 gene affect morphine pharmacokinetics. Biochem Pharmacol. 2013;86:666-678.

17. Crews KR, et al. Clinical pharmacogenetics implementation consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014;95:376-382.