Drug Interactions Where Both Drugs are Affected

November 2017

John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD

References:

1. Zhang C, Shen L, Cui M, Liu X, Gu Z. Ticagrelor-induced life-threatening bleeding via the cyclosporine-mediated drug interaction. A case report. Medicine. 2017;96:e8065. doi:10.1097/MD.0000000000008065

2. Horn JR, Hansten PD, Chan L-N. Proposal for a New Tool to Evaluate Drug Interaction Cases. Ann Pharmacotherapy. 2007;41:674-680.

3. van Sloten, de Klaver PAG, ven den Wall Bake AWL. Co-administration of cyclosporine and ticagrelor may lead to a higher exposure to cyclosporine: a case report of a 49-year-old man. Br J Clin Pharmacol. 2017;Sept 11: doi: 10.1111/bcp.13433