Pharmacy Times – September 2016

 

Drug Interactions: Insights and Observations

 

Different Outcomes Depending on Indication

 

John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD

 

 

References

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2. Houben HG, Thien T, van Õt Laar A. Effect of low-dose epinephrine infusion on hemodynamics after selective and nonselective β-blockade in hypertension. Clin Pharmacol Ther. 1982;31:685-690.

3. Johnsson G. Influence of metoprolol and propranolol on hemodynamic effects induced by adrenaline and physical work. Acta Pharamcol et Toxicol. 1975:36(suppl. V):59-68.

4. Dzubow LM. The interaction between propranolol and epinephrine as observed in patients undergoing MohsÕ surgery. J Am Acad Dermatol. 1986;15:71-75.

5. Foster CA, Aston SJ. Propranolol-epinephrine interaction: a potential disaster. Plast Reconstr Surg. 1983;72:74-78.

6. Hansbrough JF, Near A. Propranolol-epinephrine antagonism with hypertension and stroke. Ann Intern Med. 1982;92:717.

7. Greenberger PA. Fatal and near-fatal anaphylaxis: factors that can worsen or contribute to fatal outcomes. Immunol Allergy Clin N Am. 2015;35:375-386.