Pharmacy Times – February 2009

 

Drug Interactions: Insights and Observations

 

Drug Transporters: The Final Frontier for Drug Interactions. Part 2

 

John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD

 

 

References

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3.     Muck W et al. Increase in cerivastatin systemic exposure after single and multiple dosing in cyclosporin-treated kidney transplant recipients. Clin Pharm Ther. 1999;65:251-61.

4.     Griffith RS et al. Effect of probenecid on the blood levels and urinary excretion of cefamandole. Antimicrob Agents Chemother. 1977;11:809-12.

5.     Kimura H et al. Metformin isa superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1. Drug Metab Pharmacokinet. 2005;20:379-86.

6.     Somogyi A et al. Reduction of metformin renal tubular secretion by cimetidine in man. Br J Clin Pharmacol.1987;23:545-51.

7.     Wang ZJ et al. OCT2 polymorphisms and in-vivo renal functional consequence: studies with metformin and cimetidine. Pharmacogenet Genomics. 2008;18:637-45.

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9.     Bauer LA et al. Levofloxacin and ciprofloxacin decrease procainamide and n-acetylprocainamide renal clearances. Antimicrob Agents Chemother. 2005;49:1649-51.

10.  Somogyi A et al. Cimetidine-procainamide pharmacokinetic interaction in man: evidence of competition for tubular secretion of basic drugs. Eur J Clin Pharmacol. 1983;25:339-45.