Pharmacy Times – April 2008

 

Drug Interactions: Insights and Observations

 

Clopidogrel: Interactions May Lead to Loss of Antiplatelet Activity

 

John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD

 

 

References

1. Gilard M et al. Influence of omeprazole on the antiplatelet action of clopidogrel associated to aspirin. J Thromb Haemost. 2006;4:2508.
2. Gilard M et al. Influecne of omeprazole on the antiplatelet action of clopidogrel associated with aspirin. J Am Col Card. 2008;51:256.
3. Matetzky S et al. Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarction. Circulation. 2004;109:3171.