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PHARMACY TIMES

 

Drug Interactions: Insights and Observations

 

John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD

 

 

 

Narcotic Analgesic Metabolized by CYP2D6

 

 

References:

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  4. Gasche Y et al. Codeine intoxication associated with ultrarapid CYP2D6 metabolism. NEJM.2004;351:2827.
  5. Wilder-Smith CH et al. The visceral and somatic antinociceptive effects of dihydrocodeine and its metabolite, dihydromorphine. A cross-over study with extensive and quinidine-induced poor metabolizers. Br J Clin Pharmacol.1998;45:575.