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Goldenseal Drug Interactions
September 2012
John R. Horn, PharmD, FCCP, and Philip D. Hansten, PharmD
References:
1. Gurley BJ et al. Effect of goldenseal (Hydrastis Canadensis) and kava kava (Piper methysticum) supplementation on digoxin pharmacokinetics in humans. Drug Metab Dispos. 2007;35:240-245.
2. Guo Y et al. Repeated administration of berberine inhibits cytochromes P450 in humans. Eur J Clin Pharmacol 2012;68:213-217.
3. Gurley BJ et al. In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4 phenotypes. Clin Pharmacol Ther. 2005;77:415-426.
4. Gurley BJ et al. Supplementation with goldenseal (Hydrastis Canadensis), but not kava kava (Piper methysticum), inhibits human CYP3A4 activity in vivo. Clin Pharmacol Ther. 2008;83:61-69.
5. Wu X et al. Effects of berberine on the blood concentration of cyclosporine A in renal transplanted recipients: clinical and pharmacokinetic study. Eur J Clin Pharmacol. 2005;61:567-572.
6. Gurley BJ et al. Clinical assessment of CYP2D6-mediated herb-drug interactions in humans: effects of milk thistle, black cohosh, goldenseal, kava kava, St. JohnÕs wort, and Echinacea. Mol Nutr Rood Res. 2008;52:755-763.