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Pharmacy Times – April 2017

 

Drug Interactions: Insights and Observations

 

Metformin and Organic Cationic Transporter Interactions

 

John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD

 

 

 

References

 

1. Wagner DJ, Hu T, Wang J. Polyspecific organic cation transporters and their impact on drug intracellular levels and pharmacodynamics. Pharmacol Res. 2016;111:237-46. Doi:10.1016/j.phrs.2016.06.002.

2. Cho SK, Kim CO, Park ES et al. Verapamil decreases the glucose-lowering effect of metformin in healthy volunteers. Br J Clin Pharmacol. 2014;78:1426-32. Doi: 10.1111/pcp.12476.

3. Ahlin G, Chen L, Lazorova L, et al. Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1: predictions of metformin interactions. Pharmacogenomics J. 2011;11:400-11. Doi. 10.1038/tpj.2010.54.

4. Cho SK, Yoon JS, Lee MG et al. Rifampin enhances the glucose-lowering effect of metformin and increases OCT1 mRNA levels in healthy participants. Clin Pharmacol Ther. 2011;89:416-21. Doi.:10.1038/cpt.2010.266.