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Pharmacy Times – December 2014

 

Drug Interactions: Insights and Observations

 

Drug Interactions with Marihuana

 

John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD

 

 

 

 

References

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2.  Fusar-Poli P et al. Distinct effects of delta 9-tetrahydrocannabinol and cannabidiol on neural activation during emotional processing. Arch Gen Psychiatry. 2009;66:95-105.

3.  Watanabe K et al. Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes. Life Sci. 2007;80:1415-9.

4.  Sachse-Seeboth C et al. Interindividual variation in the pharmacokinetics of delta9-tetrahydrocannabinol as related to genetic polymorphisms in CYP2C9. Clin Pharmacol Ther. 2009;85:273-6.

5.  Stout SM et al. Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: a systematic review. Drug Metab Rev. 2014;46:86-95.

6.  Jiang R et al. Identification of cytochrome P4540 enzymes responsible for metabolism of cannabidiol by human liver microsomes. Life Sci. 2011;89:165-70.

7.  Yamreudeewong W et al. Probable interaction between warfarin and marihuana smoking. Ann Pharmacother. 2009;43:1347-53.

8.  Jusko WJ et al. Factors affecting theophylline clearances: age, tobacco, marijuana, cirrhosis, congestive heart failure, obesity, oral contraceptives, benzodiazepines, barbiturates, and ethanol. J Pharm Sci. 1979;68:1358-66.