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Pharmacy Times – November 2014

 

Drug Interactions: Insights and Observations

 

Codeine Drug Interactions

 

John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD

 

 

References.

 

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2. Sanfilippo G. Experimental contribution to the hypothesis of demethylation of codeine in the organism. III. Habituation to morphine obtained by prolonged administration of codeine. Boll Soc Ital Biol Sper 19:29:1761-3.

3. Sanfilippo G. The demethylation of codeine in vivio. Arch Ital Sci Farmacol. 1953;3:357-66.

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8. Bertilsson L et al. Extremely rapid hydroxylation of debrisoquine: a case report with implication for treatment with nortriptyline and other tricyclic antidepressants. Ther Drug Monit 1985;7:478-80.

9. Johansson I, et al. Interhited amplification of an active gene in the cytochrome P450 2D-locus as a cause of ultrarapid metabolism of debrisoquine. Proc Natl Acad Sci 1993:90:111825-9.

10. Dalen P, et al. Quick onset of severe abdominal pain after codeine in an ultrarapid metabolizer of debrisoquine. Ther Drug Monit. 1997:19:543-44.

11. Gasche Y et al. Codeine intoxication associated with ultrarapid CYP2D6 metabolism. N Engl J Med. 2004;351:2827-31.

12. Koren G et al. Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother. Lancet. 2006;368:704.

13. Ciszkowski C, Madadi P. Codeine, ultrarapid-metabolism genotype, and postoperative death. N Engl J Med. 2009;361:827-8.

14. Caraco Y, et al. Pharmacogenetic determinants of codeine induction by rifampin: the impact on codeineĠs respiratory, psychomotor and miotic effects. J Pharmacol Exp Ther. 1997;281:330-336.

15. Meissner K, et al. Cyclosporine-inhibitable blood-brain barrier drug transport influences clinical morphine pharmacodynamics. Anesthesiology. 2013:119:941-953.

16. Tzvetkov MV, et al. Morphine is a substrate of the organic cation transporter OCT1 and polymorphisms in OCT1 gene affect morphine pharmacokinetics. Biochem Pharmacol. 2013;86:666-678.

17. Crews KR, et al. Clinical pharmacogenetics implementation consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014;95:376-382.