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Pharmacy Times – October 2013

 

Drug Interactions: Insights and Observations

 

Apixaban: An Oral Anticoagulant

 

John R. Horn, PharmD, FCCP and Philip D. Hansten, PharmD

 

 

 

 

References

 

1. Eliquis. [package insert]. Princeton, NJ, Bristol-Myers Squibb Company, 2012.

2. Zhang D et al. Characterization of efflux transporters involved in distribution and disposition of apixaban. Drug Metab Dispos. 2013;41:827-835.

3. Zrieki A et al. Cyclooxygenase inhibitors down regulate P-glycoprotein in human colorectal Caco-2 cell line. Pharm Res. 2008; 25:1991-2001.

4. Barrett YC et al. A randomized assessment of the pharmacokinetic, pharmacodynamic and safety interaction between apixaban and enoxaparin in healthy subjects. Thromb Haemost. 2012;107:916-924.